Fecha/hora: 01/06/2024 13:34:02

Biblioteca(s): 	INIA La Estanzuela.	
Fecha corriente: 	13/09/2017	
Fecha de la última actualización: 	18/09/2017	
Autoria: 	BERTON, MP.; DE OLIVEIRA SILVA, R.M.; PERIPOLLI, E.; STAFUZZA, N.B.; FERNÁNDEZ, J.; SAURA, S.; VILLANUEVA, B.; TORO, M.A.; BANCHERO, G.; OLIVEIRA, P.S.; ELER, J.P.; BALDI, F.; FERRAZ, J.B.S.	
Afiliación: 	Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, España.; Animal Production Department, Universidad Politécnica de Madrid, Madrid, España.; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; University of Sao Paulo, Pirassununga, Brazil.; NAP-GMABT/ FZEA/University of Sao Paulo, Pirassununga, Brazil.; FERNANDO BALDI, Department of Animal Science, School of Agricultural and Veterinarian Sciences, Sao Paulo State University, Jaboticabal, Brazil.; NAP-GMABT/ FZEA/University of Sao Paulo, Pirassununga, Brazil.	
Título: 	Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed.	
Año de publicación: 	2017	
Fuente/Imprenta: 	Journal of Animal Science, 2017, v.95, suppl.4.p.107.	
DOI: 	10.2527/asasann.2017.216	
Idioma: 	Inglés	
Contenido: 	Abstract. 
The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with
resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adapted
to tropical climate. The degree of anemia assessed by the FAMACHA card (FAM) and the egg counts per gram of feces
(EPG) were evaluated to verify the resistance to gastrointestinal parasites. A total of 576 animals were genotyped using
12,785 SNPs of the Ovine SNP12k BeadChip (Illumina, Inc.). The variance components were estimated using a single trait
model by single step genomic BLUP (ssGBLUP) procedure.The overall LD mean between marker pairs measured by r2
was 0.23. Heritability estimates were low for EPG (0.11) and high for FAM (0.35). A total of 22 and 21 important windows
for EPG and FAM traits were identified. The results of the enriched genes and functional grouping analyses showed that
genes associated with FAM and OPG are involved in functions related to the body?s immune and defense response. The
CCL28 gene located in OAR16 identified both for EPG and FAM acts as a chemotactic for CD4 and CD8 inactive T cells.
The metabolic pathway involved in the CCL28 gene and in other genes associated with EPG and FAM, which are related
to immunoglobulin synthesis in the intestine. The high heritability observed for FAM suggests that good genetic progress
should be possible in selective breeding programs for Santa Inês sheep besides the fact that the FAM is the most
precise method to identify an infection by Haemonchus when compared to EPG. This study reported for the first time estimates
of linkage disequilibrium between markers and genetic parameters for traits related to gastrointestinal parasite resistance
in the Santa Inês sheep breed.	
Palabras-Clave: 	GWAS; LINKAGE DISEQUILIBRIUM; RAZAS DE OVEJAS TROPICALES; RESISTENCIA A PARÁSITOS GASTROINTESTINALES.	
Categoría del tema: 	E16 Enfermedades de los animales	
Registro original: 	INIA La Estanzuela (LE)	
Ejemplares: 	LE - (102193-1) - PXI - AP - DD -  -  -  - DIS